What Are Kidney Stones? Symptoms, Causes, Diagnosis, Treatment, and Prevention
Kidney stones are common — if you haven’t had a kidney stone, you likely know someone who has. Kidney stones affect 1 in 5 men and 1 in 10 women in the United States by the time they are 70 years old. (1)
Kidney stones (also called nephrolithiasis or urolithiasis) are hard, rock-like deposits that form in the kidneys. (1) Kidney stones typically develop when there is too much waste and not enough fluid in the kidneys. (2)
Passing a stone — the process of the stone moving out of the kidney and into and through the ureter (the tube that carries urine to the bladder) — can be excruciating. (3) “Some women say the pain is worse than childbirth,” says Naim Maalouf, MD, a professor of internal medicine at University of Texas Southwestern Medical Center in Dallas.
Your body’s waste can include minerals and other substances that combine to form stones, ranging in size from a grain of sand to the size of a pea, or even as large as a golf ball. (4,5)
There are two main types of kidney stones: calcium stones and noncalcium stones, explains Ganesh Shidham, MD, an associate professor of nephrology at the Ohio State University Wexner Medical Center in Columbus. High levels of calcium in the urine account for about 70 to 80 percent of all kidney stones. (6) Calcium can bind with other substances in the urine, such as oxalate and phosphate, to form stones. (7)
Stones that do not contain calcium include:
Kidney stones can form in one or both kidneys. While in the kidney, a stone may not cause any symptoms. Likewise, stones that are as small as a grain of sand may pass out of the body unnoticed. But if a larger stone travels down a ureter, it can create a blockage that causes pain and a variety of other symptoms. (7)
Fortunately, a number of effective treatment options are available, many of which are minimally invasive. Moreover, doctors can perform tests to determine what caused your kidney stone and develop a plan for lifestyle changes and medication to prevent future ones, says Dr. Maalouf.
Pain is a classic symptom of kidney stones, says Prakash N. Maniam, MD, a urologist at HCA Florida Healthcare in Oviedo, Florida. The pain is usually sharp and felt along the sides of the torso. It may radiate around to the abdomen and into the groin area as the stone moves through the urinary tract system, he says.
As the stone moves along the tract, it can block the natural flow of urine, which causes the kidney to swell, Dr. Maniam explains. The swelling activates nerves, which sends signals that are interpreted by the brain as an intense visceral pain, he says.
More than half a million people go to the emergency room because of kidney stones every year. (9)
Learn More About Why Kidney Stones Cause Pain
In addition to pain, blood in the urine and a burning sensation during urination are other common symptoms of kidney stones, says Maalouf. “Sometimes with severe pain, patients develop nausea and vomiting,” he adds.
“If stone pain and fever develop, go directly to the ER,” advises Timothy F. Lesser, MD, a urologist at Torrance Memorial Medical Center in Torrance, California. Fever is a sign of infection. (7) Notably, a kidney stone with a urinary tract infection (UTI) may cause sepsis (an extreme immune response to infection that can cause organ failure) and must be treated immediately. (10)
Other symptoms of a kidney stone can include frequent urination, a strong need to urinate, what looks like gravel in the urine, urine that smells bad, and cloudy urine. (1)
Learn More About Kidney Stone Symptoms and When to Seek Treatment
Some people are more likely to develop kidney stones than others. For example, men are more likely to have kidney stones than women, as are people with a family history of kidney stones, those with a history of UTIs, and those who have had kidney stones once before. (4)
You’re also more likely to develop kidney stones if you take certain medications, including: diuretics, calcium-based antacids, topiramate (Topamax) (an anti-seizure medication), and indinavir (an HIV treatment). (4) Calcium and vitamin C supplements may also increase your risk of forming kidney stones. (3)
And while medical conditions like diabetes, high blood pressure, and obesity can increase the risk of kidney stones, healthy people can also develop them, says Anil Agarwal, MD, a gastroenterologist with HVA Medical Group in Clifton, New Jersey.
Factors that may contribute to the formation of kidney stones include: (11)
Kidney stones are less common in Hispanic Americans and Black Americans. (12)
Learn More About the Different Types of Kidney Stones and What Causes Them
If you notice symptoms that suggest you have kidney stones, including sharp abdominal pain, it’s a good idea to contact your primary care provider, who will refer you to a specialist if needed. (4) Seek emergency care if you experience pain so severe that you can’t find a comfortable position to sit in, pain accompanied by nausea and vomiting, pain accompanied by fever and chills, blood in your urine, or trouble passing urine. (7) And even if you don’t need medications to help pass a kidney stone or cope with the pain of passing it, it’s a good idea to see your doctor for a urinalysis test to determine the cause of the stone and discover ways to prevent more stones.
If your doctor suspects you have a kidney stone, he or she will likely ask you about your personal and family medical history to determine if you’re genetically predisposed to kidney stones or if you have any medical conditions that could increase your risk, such as diabetes. Your doctor may also ask about your dietary habits, especially those that may increase your risk of stones. (3)
You can also expect to receive a physical exam and undergo some combination of imaging tests, urine tests, and blood tests to look for an underlying diagnosis and factors contributing to the stones. Some of these tests can help determine the cause of your stones. (7)
The most common imaging tests used for diagnosing kidney stones are a computerized tomography (CT) scan (which creates three-dimensional images of the body) or an ultrasound (which uses sound waves to create real-time images). (7,13,14)
Imaging tests should examine the kidneys, the ureters, and the bladder for the stone, says Sean Hashmi, MD, a nephrologist at Kaiser Permanente in Woodland Hills, California.
Urine tests may include the following:
In addition to imaging tests and urine tests, your doctor may order blood tests, which may help identify underlying conditions contributing to stones, detect anemia, diagnose infection, and measure electrolytes (salts and minerals that may be altered because of a kidney stone), says Hashmi. Blood tests can also help doctors check kidney function. (7)
Finally, if you pass a stone, you should bring it to your doctor for a stone analysis, says Dr. Shidham. They vary in size and shape, and may be as small as a grain of sand, or as large as a pea. Generally, kidney stones look like yellow or brown pebbles, and may have smooth or jagged edges. (4) On the basis of the results, doctors may be able to determine the type of stone and then prescribe certain drugs or recommend specific lifestyle changes that help to prevent another one, he adds.
Learn More About Kidney Stone Diagnosis and What to Know Before Your Appointment
A kidney stone often goes unnoticed until it starts to pass into your ureters. (7) Once this happens, symptoms typically appear without warning. You’ll likely feel sharp, stabbing pain at the bottom of your ribcage, though the pain can shift into the genital area as well. (17)
The pain from kidney stones often comes in waves, and you may feel better for a few hours before the pain comes back. (17)
Depending on the size of the stone, it can take up to six weeks to pass (though many patients opt for interventions within that time frame). Small stones may take only a few days to a week to pass. Your doctor will likely prescribe medications to help you manage the pain during this time. (17)
You may not always need treatment for a kidney stone. A small stone can pass through the urinary tract without intervention. But larger stones can block the ureter and cause pain and other symptoms. (7)
Kidney stone pain can be severe at first and may require carefully administered narcotics for relief, says Ralph V. Clayman, MD, a professor in the department of urology at the University of California in Irvine. Subsequent pain can often be managed using nonsteroidal anti-inflammatory (NSAID) medication, he says.
Drinking enough water (roughly 64 ounces) to produce at least two liters of urine each day can help to pass the stone. (7) In addition, doctors may prescribe tamsulosin (Flomax), which is a medication that relaxes the muscles of the ureter and helps the stone pass, says Dr. Lesser.
If a stone is too big to pass or a patient has an intolerable amount of pain, doctors may intervene with procedures that either break up or remove the stones, says Lesser.
These procedures include:
Kidney stones call for conventional medical care, so don’t try to treat kidney stones with alternative therapies. (22)
Whether you’ve passed a kidney stone on your own, have undergone a procedure to remove or break one up, or you’ve never had one before, there are things you can do that help prevent new stones from forming. In fact, if you pass a kidney stone without addressing the root cause, chances are more will develop over time. (23) A variety of lifestyle changes and medicines can help prevent this from happening.
Your doctor can determine which approach is right for you (be it lifestyle changes, medication, or a combination) based on the type of stone you may have had in the past and the rest of your medical history, says Maalouf.
Lifestyle changes that can decrease the risk of developing a stone include:
Drugs used to prevent kidney stones include: (3)
In addition to obesity, high blood pressure, and diabetes, underlying health problems, such as hyperparathyroidism (an overactive parathyroid gland) and inflammatory bowel disease (like Crohn’s disease), can also raise your risk of developing kidney stones. (7) Managing these conditions can help prevent future stones.
Some serious risks are associated with kidney stones. Left untreated, a kidney stone can block the ureters or make them narrower, increasing your risk of developing a kidney infection known as pyelonephritis (a type of UTI). (23) A kidney infection requires immediate medical attention. Otherwise, the infection can cause permanent kidney damage or spread to your bloodstream, leading to a potentially fatal infection (sepsis). (27)
While rare, kidney stones may damage your kidney if they cause infection or blockage. (3) Damage to the kidney can lead to a gradual loss of function over time, a condition known as chronic kidney disease. (28)
Kidney stones are becoming more and more common. (4,12) In the late 1970s, roughly 3.8 percent of the U.S. population were affected by kidney stones. Now 19 percent of men and 9 percent of women are expected to have a kidney stone at some point in their lives. (9)
Research based on data collected from 2007 to 2014 found that men older than 60 had the highest prevalence of kidney stones (17.8 percent) among all age groups during this time period, followed by men between ages 40 and 59 (12.6 percent). While the prevalence of kidney stones among men older than 60 remained stable during this time period, the prevalence of kidney stones in women ages 20 to 39 nearly doubled between 2007 and 2013 (3.9 to 7.5 percent).
When the researchers analyzed the data by race, though, they found that kidney stone incidence among non-Hispanic white women did not increase at all, but non-Hispanic Black women and Hispanic women saw a significant increase, suggesting that those minority populations accounted for the increase in kidney stone incidence among women. More research is needed to figure out why, but the study authors suggest higher rates of obesity among non-Hispanic Black women and Hispanic women compared with non-Hispanic white women may be part of the explanation. (29)
If you think you may have a kidney stone, it’s important to check with your doctor. Your doctor can perform imaging tests to look for other issues that may be causing your abdominal pain, such as appendicitis, pancreatitis, ulcerative colitis, pelvic inflammatory disease, and stomach ulcers. (30)
Kidney stones are also often associated with UTIs, which develop when bacteria makes its way into your kidneys, ureters, bladder, or urethra and causes an infection. People with blockages in their urinary tract (including kidney stones) face a higher risk of UTIs. (31)
Kidney stones and UTIs share a few symptoms, such as abdominal pain; cloudy, blood-tinged, or foul-smelling urine; and a constant need to urinate. If the UTI spreads to the kidneys, you may feel other symptoms also associated with kidney stones, such as pain in the lower back, fever and chills, and nausea and vomiting. (31)
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