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Chronic Kidney Disease (CKD) Treatment: Medication, Lifestyle Changes, and More

Chronic kidney disease (CKD) is a progressive condition in which the kidneys are damaged and can’t filter blood effectively. This can eventually lead to a buildup of waste and fluid in the body.

In the earlier stages of kidney disease, it’s possible to significantly slow down the progression of the disease with lifestyle changes. Treating related conditions, such as high blood pressure and diabetes, can also significantly improve your prognosis.

If the disease progresses to the point of kidney failure, there are only two treatment options: dialysis or a kidney transplant. There is currently no cure for CKD, and any loss of kidney function is irreversible.

If you have CKD, talk to your healthcare professional before starting a treatment or combining treatments, and discuss what’s best for you.

A number of prescription drugs can help manage CKD, including ones that help treat diabetes and high blood pressure, two health conditions that are closely linked to this disease.

Sodium-Glucose Cotransporter-2 (SGLT2) Inhibitors

These drugs were developed to treat type 2 diabetes, but they are also effective at slowing down CKD progression.

SGLT2 inhibitors work by helping your kidneys remove more sugar and salt from your body through the urine. Medications in this class include:
  • canagliflozin (Invokana)

  • dapagliflozin (Farxiga)
  • empagliflozin (Jardiance)
Canagliflozin is an option specifically for people who have type 2 diabetes and CKD, but dapagliflozin and empagliflozin can both be used by people with CKD who don’t have diabetes.

Some possible side effects include more frequent urination, low blood pressure, and a decrease in estimated glomerular filtration rate (eGFR), which is a measurement of how well your kidneys are filtering waste and excess fluid from your blood.

Glucagon-Like Peptide-1 (GLP-1) Receptor Agonists

Better known as the drug class that includes the weight loss phenomenon Ozempic (semaglutide), GLP-1s have also been approved by the U.S. Food and Drug Administration to treat people with type 2 diabetes and chronic kidney disease. These drugs protect the kidneys from damage by lowering blood sugar.

Other mediations in this class include:
  • tirzepatide (Mounjaro, Zepbound)
  • dulglutide (Trulicity)
  • extendatide (Bydureon)
  • liraglutide (Victoza)

Renin-Angiotensin System Inhibitors (RASi)

This is a broader classification of drugs that includes ACE inhibitors and angiotensin II receptor blockers (ARBs). Both medications can help protect the kidneys, and they’re also prescribed for high blood pressure and heart failure.

 Joseph A. Vassalotti, MD, chief medical officer of the National Kidney Foundation and clinical professor with the Icahn School of Medicine at Mount Sinai, says these drugs are often one of the first medications prescribed for CKD.
Medications in the ACE inhibitor class include:

  • lisinopril (Prinivil, Zestril)
  • perindopril (Aceon)
  • ramipril (Altace)
Medications in the ARB class include:

  • losartan (Cozaar)
  • olmesartan (Benicar)
  • valsartan (Diovan)
Common side effects of ARBs and ACE inhibitors include possible blood pressure drops, fatigue, and cough, which is more common with ACE than ARB medications.

Statins

Statins are medications that lower cholesterol to improve blood flow and help prevent cardiovascular disease. Some evidence suggests that these meds may help with inflammation and slow down CKD progression.

Statins are considered a first-line therapy in people with CKD.

Some examples of statins include:

  • atorvastatin (Lipitor)
  • rosuvastatin (Crestor)
  • simvastatin (Zocor)
Possible side effects of statins include digestive problems, mental fuzziness, and muscle pain.

If your kidney disease progresses to kidney failure (end-stage kidney disease), your kidneys will no longer be able to work well enough to keep you alive. As a result, you will need a more serious intervention.

Dialysis, a treatment that filters waste and excess fluid from the blood, is one option. Options for dialysis include:

  • Hemodialysis: This is the most common type. Hemodialysis can be done at home or in a dialysis center. It uses a machine that removes blood from a surgically created connection in your arm, filters it through an artificial kidney known as a dialyzer, and returns the cleaned blood to your body. Alternatively, a catheter may be placed in the upper chest. In-clinic visits are usually three days a week, while in-home dialysis may be daily.

  • Peritoneal dialysis: This type uses the lining of your abdomen to filter blood. There is no machine required, and it’s done every day at home. There is an initial surgery so that doctors can place the catheter for future fluid exchange.

  • Hemodiafiltration: This type is is similar to hemodialysis, but it adds an extra filtration process that removes more waste products from the blood. It’s not widely used in the United States, but it has a positive effect on mortality rates.

Dialysis is a significant burden, and it can greatly impact your quality of life.

Dr. Vassalotti says that in-center dialysis can be especially hard for patients, since it can be time consuming. Patients need to come in “usually three times a week, for three to five hours,” he says. Patients can feel drained after dialysis treatment, often have to be on multiple medications, and can also struggle with the restricted diet that is necessary with this treatment.

A kidney transplant may be the best option for people who have end-stage kidney disease. Compared to people who stay on dialysis, people who get a kidney transplant may live for about 10 years longer.

“A preemptive transplant is the first treatment for kidney failure,” says Vassalotti. He adds that receiving a kidney from a live donor is the best way to obtain a healthy organ, and transplants are typically better for quality of life than dialysis.

Potential transplant recipients need to go through a transplant evaluation, which can involve multiple visits with specialists and evaluation tests, and many people spend two to five years on the wait list. A kidney transplant surgery takes about five hours, and patients may spend a week at the hospital recovering.

After surgery, it could take several weeks for the kidney to start functioning. Dialysis may be necessary during this waiting time.

People who receive a kidney transplant will need to take immunosuppressive medications for the rest of their lives to prevent their bodies from rejecting the organ. These medications may have unpleasant side effects like nausea and can increase infection risk.

Your diet can have a big impact on kidney health, and making healthy changes can significantly slow the progression of this chronic disease.

There is no one-size-fits-all kidney health diet. Your own dietary needs may be different based on the stage of their CKD and other health factors, and they may change throughout the course of your treatment and progression.

“Most people with kidney disease should see a registered dietitian for medical nutrition therapy,” says Vassalotti. You should discuss these nutrients with your healthcare team.

  • Protein: Your body breaks protein down into waste that’s removed from the blood. Some people with CKD may be advised to avoid eating too much protein, since this can make kidney function worse.

    Choosing plant-based sources of protein, like nuts, beans, and tofu, may also help slow CKD progression.

  • Potassium: When the kidneys aren’t functioning properly, potassium levels can become high, leading to heart and muscle problems. High potassium is a risk in later stages of CKD, but even people who need to limit potassium should still eat plenty of fruits and vegetables for the other health benefits they offer.

  • Sodium: Sodium is extremely common in processed and frozen foods, and keeping track of your salt intake can be beneficial for your kidney health. Limiting sodium might help with CKD progression and blood pressure.
  • Phosphorous: Phosphorus, an important mineral, can build up in the bloodstream of people with CKD and harm your blood vessels and bones.

    Phosphorus is found in a wide variety of foods, including dairy products, salmon, meat, and poultry.

    The risk of phosphorus getting too high is typically greater later on in CKD.

Many people with CKD, especially during its earlier stages, will not have to limit nutrients like potassium and phosphorus. Choosing a healthy diet with plenty of fruits, veggies, whole grains, and minimally processed ingredients is a great start. Vassalotti recommends thinking about your overall dietary pattern and following healthy guidelines such as the U.S. Department of Agriculture’s MyPlate concept. “Such an approach is more optimistic and useful than the focus on avoidance of certain foods,” he says.

Beyond following a relatively strict eating plan, other lifestyle changes may help slow down the progression of chronic kidney disease, improve quality of life, and minimize the chances of kidney failure.

  • Stay active: More physical activity might help slow down worsening kidney function, although there is a need for more research.

    Physical activity can also help decrease heart disease risk and improve sleep.

  • Maintain a healthy weight: Both obesity and being underweight can pose risks for those who have CKD. Carrying extra weight can make the kidneys work harder, and being underweight is associated with an increased risk of developing end-stage kidney disease.

  • Avoid excessive alcohol: Binge drinking may contribute to CKD progression.

    The Centers for Disease Control and Prevention recommends that people with CKD limit alcohol because of its impact on blood pressure.

  • Stop smoking: Smoking may speed the progression of CKD.

     Quitting smoking can also help decrease risk of premature death from cardiovascular disease.

Vassalotti says that diabetes, hypertension, heart disease, heart failure, and obesity are common conditions that often coexist with kidney disease. Treating those conditions can help control or slow the progression of your CKD.

  • Manage blood pressure. Good blood pressure control helps decrease the risks of cardiovascular events and all-cause mortality.

  • Lower cholesterol levels. Lowering your cholesterol can help decrease the risk of atherosclerotic cardiovascular disease in those with CKD.

  • Stay on top of diabetes. Because these two health conditions are so closely interconnected, it’s essential to manage both. High blood sugar can speed up the decline of kidney function.

Your doctor may also prescribe a variety of other medications to treat the side effects or complications of chronic kidney disease. Diuretics, for example, can help treat the swelling and fluid retention that often accompanies kidney decline. Iron supplements may be necessary to treat anemia, a possible complication of CKD. And potassium binders can help your body clear excessive amounts of potassium.

  • Chronic kidney disease is a progressive condition, but it can be managed through treatment. There currently is no cure.
  • Medications such as SGLT2 inhibitors, GLP-1 receptor agonists, renin–angiotensin system inhibitors, and statins can all help slow the progression of the disease.
  • Dialysis and kidney transplants are the only treatment options for those who have more advanced CKD.
  • Modifying your diet, staying active, and quitting smoking and drinking alcohol can also help give those with CKD a better quality of life.

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